Decisions, decisions

So I'm exploring a new opportunity, with a new employer in a familiar but distant city. New opportunity offers more responsibility, interesting tasks and a chance to help out Mother Earth while making a profit. Only problem is that this is a start-up and will not necessarily succeed. With a wife and kids to think about what do I do? Wife is very supportive so it should be an easy decision, if I am ultimately offered the position. I guess we all get comfortable in our lives and uprooting ourselves to try something new is tough. But do I want to remain a corporate drone for the rest of my working days? This is an opportunity to grab the brass ring. Also, as I was told recently, if you want to get anywhere you have to step out in traffic. I think I need to go for a ride and think.